Mihály Vöröslakos

Postdoctoral Researcher

NYU Grossman School of Medicine

Buzsaki Lab

I am a postdoctoral researcher from the Buzsáki lab at NYU School of Medicine in New York. Currently, I am studying how non-invasive brain stimulation interacts with ongoing brain activity.

My approach combines brain stimulation in rodents with large-scale electrophysiology using Neuropixels and flexible probes, optogenetics using μLED and waveguide probes, fiber-photometry, and BOLD-fMRI.

Through my multi-disciplinary approach, I acquired first-hand knowledge about the challenges of translational neuroscience. Testing brain stimulation in animals and humans during my MD/PhD has made me aware of the progress needed for TES to become a reliable experimental and therapeutical tool.
To strengthen my knowledge in neuroengineering, I spent two years in Dr. Euisik Yoon’s laboratory at the University of Michigan.

I believe in knowledge sharing, and I try to contribute by sharing my CAD designs and video tutorials.

Skills

Electrophysiology

Freely moving mice and rats

Neuropixels 2.0
Silicon probes
Flexible probes

Optogenetics

Freely moving and head-fixed mice

Optrodes
μLED probe
Waveguide probe

Brain stimulation

Transcranial Electrical Stimulation

Mice
Rats
Humans

Projects

Circuit Resonance

The term “resonance” denotes the highest level of response exhibited by a neuronal network when subjected to a periodic input limited within a particular frequency range.
The focus of my investigation lies in exploring the potential utilization of intrinsic cellular properties and network mechanisms to enhance the spatial specificity of Transcranial Alternating Current Stimulation (tACS).

TES-fMRI in rats

Integrating Transcranial Electrical Stimulation (TES) with MR imaging techniques allows allows not only to study how stimulation affects targeted brain regions but also to understand its impact on anatomical and functional connectivity. TES-fMRI can offer crucial insights into the most effective ways, locations, and timing for stimulation.

Brain-body relationships

Understanding connections between the brain and body in health and disease.

ThermoMaze

In mammals, two fundamental brain states can be readily identified by basic electrophysiological monitoring “preparative” and “consummatory” states. Revealing the significance of switching between these states for cognition requires collecting a sufficient amount of brain data and the experimental control of consummatory classes of behavior (eating, drinking and resting).

In this project, we developed the ThermoMaze, a behavioral paradigm that induces heat seeking behavior and guides mice to multiple positions in a two-dimensional cold environment.

Recent Publications

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George Verghese, Mihály Vöröslakos, Stefan Markovic, Assaft Tal, Seena Dehkharaghani, Omid Yaghmazadeh, Leeor Alon (2023). Autonomous animal heating and cooling system for temperature-regulated MR experiments. arXive.

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György Buzsaki, Mihály Vöröslakos (2023). Brain rhythms have come of age. Neuron.

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Christian Böhler, Maria Vomero, Marisol Soula, Mihály Vöröslakos, Maria Porto Cruz, Rickard Liljemalm, György Buzsaki, Thomas Stieglitz, Maria Asplund (2023). Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants. Advanced Science.

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Nathaniel R. Kinsky, Mihály Vöröslakos, Jose Roberto Lopez Ruiz, Laurel Watkins de Jong, Nathan Slager, Sam McKenzie, Euisik Yoon, Kamran Diba (2023). Simultaneous Electrophysiology and Optogenetic Perturbation of the Same Neurons in Chronically Implanted Animals using μLED Silicon Probes. bioRxiv.

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Eunah Ko, Kanghwan Kim, Mihály Vöröslakos, Sungjin Oh, György Buzsaki, Kensall D Wise, Euisk Yoon (2022). Optogenetic Neural Probes: Fiberless, High-Density, Artifact-Free Neuromodulation : (Invited). 2022 International Electron Devices Meeting (IEDM).

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